Abstract
Delivering drug molecules into the cell is one of the major challenges in the process of drug development. In past, cell penetrating peptides have been successfully used for delivering a wide variety of therapeutic molecules into various types of cells for the treatment of multiple diseases. These peptides have unique ability to gain access to the interior of almost any type of cell. Due to the huge therapeutic applications of CPPs, we have built a comprehensive database ‘CPPsite’, of cell penetrating peptides, where information is compiled from the literature and patents. CPPsite is a manually curated database of experimentally validated 843 CPPs. Each entry provides information of a peptide that includes ID, PubMed ID, peptide name, peptide sequence, chirality, origin, nature of peptide, sub-cellular localization, uptake efficiency, uptake mechanism, hydrophobicity, amino acid frequency and composition, etc. A wide range of user-friendly tools have been incorporated in this database like searching, browsing, analyzing, mapping tools. In addition, we have derived various types of information from these peptide sequences that include secondary/tertiary structure, amino acid composition and physicochemical properties of peptides. This database will be very useful for developing models for predicting effective cell penetrating peptides.Database URL: http://crdd.osdd.net/raghava/cppsite/.
Highlights
Advances in proteomics and high-throughput assays have led to the discovery of a large number of highly potent therapeutic molecules
The important feature of CPPsite is that it covers all possible types of Cell penetrating peptides (CPPs) that consists of L-amino acids (777 peptides), D-amino acids (34 peptides), both L & D amino acids (11 peptides) and non-natural amino acids (21 peptides)
In the past few years, due to the huge therapeutic potential of CPPs, a growing interest has been seen in CPP based research
Summary
Advances in proteomics and high-throughput assays have led to the discovery of a large number of highly potent therapeutic molecules. Most of these molecules do not reach the clinical trial stage due to their poor delivery and low bioavailability. Cell penetrating peptides (CPPs) based method is one of the powerful techniques used for delivering therapeutics/ drugs [3,4,5,6]. It has numerous advantages over the other delivery methods like versatility, high efficiency, low toxicity
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