Abstract
Weakness of the legs in the aged is often a manifestation of hidden malignancy. Sensory and motor nerve conduction studies were undertaken of 100 patients over the age of 65 who were undergoing pathologic neuromusculoskeletal changes. These changes, which antedate the primary malignant focus, may be subacute cerebellar degeneration, sensory neuropathy, myopathic alterations, myasthenic states, polymyositis and pathologic collagen-like changes, and multiple combinations of motor neuron disease. Clinical observations supplemented by electromyography, motor and sensory nerve conduction studies, and muscle studies made possible an objective, early, exact diagnosis of occult malignancy in eight patients.
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