Abstract
An animal’s survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environment. This is achieved through intracellular and intercellular communication within and among different tissues. One of the organ systems that plays a major role in this communication and the maintenance of homeostasis is the nervous system. Here we highlight different aspects of the neuronal inputs and outputs of pathways that affect aging and longevity. Accordingly, we discuss how sensory inputs influence homeostasis and lifespan through the modulation of different types of neuronal signals, which reflects the complexity of the environmental cues that affect physiology. We also describe feedback, compensatory, and feed-forward mechanisms in these longevity-modulating pathways that are necessary for homeostasis. Finally, we consider the temporal requirements for these neuronal processes and the potential role of natural genetic variation in shaping the neurobiology of aging.
Highlights
Neuronal inputs and outputs of aging and longevityEdited by: Nektarios Tavernarakis, University of Crete, Foundation for Research and Technology – Hellas, Greece
The study of aging is the study of an open system, where tissues and organs within the whole animal regularly exchange information with each other and with their external environment during the course of the animal’s lifespan
Here we have provided a review of the recent knowledge about the neuronal inputs and outputs that affect aging and longevity, mainly by focusing on the latest work in genetically tractable model organisms, such as flies, worms, and mice
Summary
Edited by: Nektarios Tavernarakis, University of Crete, Foundation for Research and Technology – Hellas, Greece. Reviewed by: Vassiliki Nikoletopoulou, Institute of Molecular Biology and Biotechnology, Greece Maria Markaki, Foundation for Research and Technology – Hellas, Greece Marta Artal Sanz, University Pablo de Olavide, Spain. An animal’s survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environment. This is achieved through intracellular and intercellular communication within and among different tissues. We highlight different aspects of the neuronal inputs and outputs of pathways that affect aging and longevity.
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