Abstract
Oxotremorine caused contracture of rat phrenic nerve-diaphragm followed at high doses by blockade. Similar results were obtained on the sciatic nerve-tibialis anterior muscle preparation of the cat. The slowly developing spastic paralysis obtained with high doses was long lasting. Qualitatively similar results but of lower intensity were observed on chick biventer-cervicis nerve-muscle preparation. There was no effect on frog rectus abdominis preparation. On rat diaphragm contracture and paralysis were potentiated by halving the calcium chloride concentration and by physostigmine respectively. Depolarising effect was further proven by potentiation of reduction in the force and duration of tetanic response by physostigmine on rat diaphragm. An indirect mechanism involving release of acetylcholine is postulated.
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