Abstract
Abstract Neomycin sulfate, streptomycin sulfate, dihydrostreptomycin sulfate, polymyxin B sulfate, and kanamycin sulfate produced neuromuscular blockade in the rabbit at various dosage levels. The blocking action of these five drugs, with the exception of polymyxin B sulfate, was enhanced by the simultaneous administration of d -tubocurarine chloride. Neostigmine methylsulfate antagonized the neuromuscular blockade produced by neomycin sulfate, streptomycin sulfate, and dihydrostreptomycin sulfate. Neostigmine methylsulfate tended to enhance the neuromuscular blocking action of polymyxin B sulfate and kanamycin sulfate. Tetracycline HCl, ristocetin, oleandomycin, erythromycin, bacitracin and penicillin G potassium showed no neuromuscular blocking activity. All of the antibiotics, except potassium penicillin G and ristocetin, tended to cause hypotension.
Published Version
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