Abstract
The severe acute respiratory syndrome coronavirus 2 disease (SARS-CoV-2) is the most severe manifestation of the coronavirus disease 2019 (COVID-19) pandemic. Accruing evidence indicates that the COVID-19 pandemic may have profound deleterious neurological, psychiatric, and psychological outcomes. The number of systematic reviews (SRs) and meta-analyses (MAs) on this topic has grown exponentially. This protocol aims to synthesize all evidence from SRs and MAs on the associations between the COVID-19 pandemic and neuropsychiatric outcomes. The following electronic databases will be systematically searched from inception up to 15 January 2022: PubMed, Embase, APA PsycINFO, and Cochrane Reviews. An umbrella review (UR) of SRs and MAs of observational studies will be conducted. SRs and/or MAs of observational studies examining any direct or indirect association of COVID-19 with the neuropsychiatric outcomes will be deemed eligible for potential inclusion in this UR. The direct associations include the impact on the (1) prognosis of COVID-19 and (2) neuropsychiatric sequelae after COVID-19 infection. The indirect associations include the influence of the COVID-19 pandemic on the (1) treatments and (2) outcomes of neurological and psychiatric conditions associated with the COVID-19 pandemic.
Highlights
In December 2019, the world witnessed the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which posed an extraordinary threat to global public health and human safety [1]
We propose to undertake an umbrella review to summarize and synthesize evidence from observational studies reporting on bidirectional associations of the COVID-19 infection with neurological, psychiatric, and psychological outcomes in a direct or indirect manner
The PubMed, Embase, APA PsycINFO, and Cochrane Reviews computerized databases will be systematically searched from inception to 15 January 2022, with no date or language restrictions, to identify systematic reviews (SRs) and MAs on the associations between COVID-19 and neurological, psychiatric, and psychological outcomes
Summary
In December 2019, the world witnessed the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which posed an extraordinary threat to global public health and human safety [1]. SARS-CoV-2, a highly contagious and pathogenic virus, rapidly disseminated across the world, causing a pandemic of coronavirus disease 2019 (COVID-19). The COVID-19 pandemic presents unprecedented challenges to the lives of people around the world. It has caused devastating impacts on livelihood, society, health care systems, and economic activity [9,10]. Major stressors may include social restrictions, lockdowns, boredom, loneliness, infection fears, conflicting messages from authorities, inadequate supplies, financial loss, stigma, and shifting priorities of governments in their attempt to control COVID-19 outbreaks [9–12]. A global study reported an increase of 27.6% and 25.6%, in the prevalence of major depressive disorder and anxiety disorders, respectively, since before the pandemic [13]
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