Abstract
Nervous system (NS)affectionmay occur in Eosinophilic Granulomatosis with Polyangiitis (EGPA), butitsclinical manifestations and pathophysiologyare rarely described. Our aims are to characterizecentralandperipheralNS (CNS/PNS) involvement and comparebiologicalmarkers inEGPApatients with and without neurological manifestations. Retrospective observational study, including EGPA patients with and without neurological manifestations. Demographics, clinical data, andimmunological markers were analyzed. Descriptive and inferential statistics were performed. Sixteenpatientswereincluded;11 (68.8%) ofwhom were male, with a mean age of 63.38years;8 with (Group 1) and 8 without (Group 2) neurologicalfindings.Neurological impairment preceded EGPA diagnosis in 5 patients, and occurred during follow-up in 3 patients after a median of 4.0years.CNS manifestations observed were stroke (n = 2), bilateralcentral retinal artery occlusion(n = 1), and compressive dorsal myelopathy due to extradural granulation tissue (n = 1). PNSmanifestationswere axonal polyneuropathy (n = 3), sensorineural hearing loss (n = 3), and multiplex mononeuropathy (n = 1). Two patients had both PNS and CNS involvement. There were no statistical differences regarding biological markers [eosinophil count, myeloperoxidase (MPO) antibodies titers] between the 2 groups.One patient from Group 1 wasunresponsive to treatmentandpermanent neurological sequelaewere observed in 7 cases. EGPA-related NS involvement can be heterogeneousandisresponsible for long-term sequelae. In our sample,themainneurological scenarios wereperipheral neuropathy, VIIIcranial nerve neuropathy,ischemic lesions and compressivemyelopathy.Patientswith andwithoutneurological manifestations did notdiffer ineosinophilic count and MPO titer.
Published Version
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