Abstract
Neurological complications are an important source of morbidity and mortality in individuals with Neurofibromatosis type 1 (NF1). Mild cognitive impairment is the commonest complication. Neurological complications can arise from tumours of the central and peripheral nervous system and as a consequence of bony dysplasia of the skull and spine. Neurofibromas can cause peripheral nerve, spinal nerve root, and cord compression. Diffuse neurofibromatous infiltration in peripheral nerves can result in a neuropathy. Malignant peripheral nerve sheath tumours typically arise within pre-existing plexiform neurofibromas and are highly aggressive, often with a poor prognosis. Epilepsy, vascular disease, and multiple sclerosis occur with increased frequency in NF1. Individuals with NF1 require regular review by a clinician familiar with NF1 and patient education to help them recognise symptoms that require review. Neurological complications of NF1 should be managed within a specialist multidisciplinary team.
Published Version
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