Neuroleptic Drugs Affect Sympathetic and Thermogenic Reactions to Orexin A

Viggiano A Chieffi S

doi:10.4172/1994-8220.1000172

Abstract

Neuroleptic Drugs Affect Sympathetic and Thermogenic Reactions to Orexin A

Highlights

A neuropetide takes the name of orexin A since this peptide affects food intake [1,2,3]
This review of our literature describes the effects of many neuroleptic drugs on the sympathetic and hyperthermic reactions due to orexin A, a neuropeptide affecting body temperature and food intake by an increase in sympathetic activity
Viral retrograde tracing from interscapular brown adipose tissue (IBAT) and cholera toxin retrograde tracing from the rostral raphe pallidus indicated that a population of orexin neurons in the perifornical region of the lateral hypothalamus is synaptically connected to IBAT via a direct projection from the perifornical region of the lateral hypothalamus to the rostral raphe pallidus

Summary

Neuroleptic Drugs Affect Sympathetic and Thermogenic Reactions to Orexin A

Messina G1, Viggiano A2, Chieffi S1, Viggiano E1, Tafuri D4, De Luca V3, Messina A1 and Monda M1* 1Department of Experimental Medicine, Section of Human Physiology, and Clinical Dietetic Service, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy 2Department of Medicine and Surgery, University of Salerno, Salerno, Italy 3Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada 4Department of Motor Sciences, University of Naples "Parthenope", Naples, Italy.

Introduction

Experimental Evidences

Findings

Discussion