Abstract
In the 198Os, several consensus conferences about the diagnosis of dementia were organized which dealt, amongst other topics, with the question of which neuroimaging technique might be helpful in the differential diagnosis of patients with a dementia syndrome [ 1,2]. At that time, the role of functional neuroimaging techniques such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) in the diagnosis of Alzheimer’s disease (AD) had not yet been established, but in the intervening years much information has been gathered about the diagnostic value of PET and SPECT in AD. This review concentrates on the findings of PET and SPECT in patients with AD and attempts to answer the question whether both techniques are ready for use in clinical practice. Both modalities will be discussed with regard to the contribution of each techqique to the early diagnosis of AD in the individual patient, the relation between imaging characteristics and clinical symptoms, and findings related to the possible heterogeneity of the disease.
Published Version
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