Neurogenesis is negatively altered in the dorsal vagal complex by chronic immobilization stress in the adult rat

Abstract

Event Abstract Back to Event Neurogenesis is negatively altered in the dorsal vagal complex by chronic immobilization stress in the adult rat Fatiha Chigr1*, Fatima Rachidi1, Stéphanie Mahaut2, Catherine Tardivel2, André Jean2, Mohamed Najimi1 and Emmanuel Moyse2 1 Lab. Génie Biologique, Faculty of Science and Techniques, Morocco 2 UMR 6231 CNRS - UMR 1147 INRA, Département de Physiologie Neurovégétative, France The dorsal vagal complex (DVC) is located in the floor of the fourth ventricle, i.e., in the caudal brainstem. It encompasses several interconnected structures: the nucleus tractus solitarius (NTS), which is the major recipient of afferent axons from the vagus nerve, the dorsal motor nucleus of the vagus nerve (DMNV), which contains the perikarya of efferent vagal preganglionic neurons, and area postrema (AP), which is a circumventricular organ lying dorsally in the middle third of the rostrocaudal extent of the DVC. The DVC is a multifunctional reflex center of the autonomic nervous system. With regard to food intake regulation, the DVC mediates the satiety reflex, i.e. the short-term blockade of ingestive behavior when caloric filling of the stomach above a given threshold is detected by vagal afferents. Long-term adaptations of food intake rely upon satiety threshold variations, which have been hypothesized to involve mechanisms of plasticity in the DVC. Several effectors of plasticity have indeed been characterized in the adult rat DVC: concentrations of PSA-NCAM and GAP-43, neurogenesis and neural stem cells and a neurogenic niche containing radial glia-like cells. The DVC thus belongs to the few neurogenic structures identified so far in the mammalian brain, along with the subventricular zone (SVZ) – olfactory bulb system, the hippocampus and the hypothalamus. The in vivo modulation of neurogenesis in the adult brain has been well documented in various models of experience-dependent plasticity in mammals. The role of neurogenesis in the DVC is unknown, but it might underlie long-term adaptations of food intake such as variations in the satiety threshold and/or stress-induced neuroadaptation. In the present study, we addressed the question of whether anorexia-inducing immobilization stress alters DVC neurogenesis, using cumulative BrdU incorporation in concert with daily applications of immobilization stress. Chronic immobilization stress induced a significant decrease in neurogenic proliferation in the DVC, which reached 50% in the area postrema. The number of newly formed neurons was also decreased by chronic immobilization stress in the DVC, and this effect was again maximal in the area postrema; the proportion of BrdU-labeled cells that were neurons was unchanged. These results further characterize neurogenesis in the DVC and suggest its involvement in the long-term regulation of food intake. Conference: 3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009. Presentation Type: Poster Presentation Topic: Stress Citation: Chigr F, Rachidi F, Mahaut S, Tardivel C, Jean A, Najimi M and Moyse E (2009). Neurogenesis is negatively altered in the dorsal vagal complex by chronic immobilization stress in the adult rat. Front. Neurosci. Conference Abstract: 3rd Mediterranean Conference of Neuroscience . doi: 10.3389/conf.neuro.01.2009.16.137 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Nov 2009; Published Online: 24 Nov 2009. * Correspondence: Fatiha Chigr, Lab. Génie Biologique, Faculty of Science and Techniques, Beni-Mellal, Morocco, fchigr@voila.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Fatiha Chigr Fatima Rachidi Stéphanie Mahaut Catherine Tardivel André Jean Mohamed Najimi Emmanuel Moyse Google Fatiha Chigr Fatima Rachidi Stéphanie Mahaut Catherine Tardivel André Jean Mohamed Najimi Emmanuel Moyse Google Scholar Fatiha Chigr Fatima Rachidi Stéphanie Mahaut Catherine Tardivel André Jean Mohamed Najimi Emmanuel Moyse PubMed Fatiha Chigr Fatima Rachidi Stéphanie Mahaut Catherine Tardivel André Jean Mohamed Najimi Emmanuel Moyse Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.