Abstract
Consistent with the goals of precision medicine to redefine illness mechanistically through elucidating the pathophysiology from gene action to symptoms, large-scale genomic studies have been linking genomic variation to continuous quantitative phenotypes. Such an approach can lead to early detection of pathological processes enabling early intervention. This paradigm shift is now applied in psychiatry with an increased focus in schizophrenia research on early identification of psychosis as the process emerges. Convergent approaches integrate phenotypic features with neurocognitive and neuroimaging measures in large-scale studies. Most studies have examined help-seeking youths.
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