Abstract
Aim of the study: To study the comparative neuroprotective activity of ethanolic extracts of E. alsinoides and C. asiatica. Method: The ethanolic extracts of E. alsinoides and C. asiatica were administered orally daily along with scopolamine for a period of 14 days following which the behavioral tests i.e. elevated plus maze and Morris water maze tests were performed to assess learning and memory. Animal groups were divided in nine different groups. In-vivo antioxidant enzymes activity, inflammatory markers inhibition activity and acetylcholinesterase (AChE) inhibition activity in the brain of mice were also measured at the end of the study. Results: The study demonstrate that scopolamine induction resulted in learning and memory deficits which were partially and significantly ameliorated by the ethanolic extracts of E. alsinoides and C. asiatica. The extracts also counteracted scopolamine-induced decreases in acetylcholine levels, increases in AChE activity, and decreases in activities of the antioxidant enzymes. The study demonstrates the ability of the ethanolic extracts of E. alsinoides and C. asiatica to reverse scopolamine-induced learning and memory deficits in mice which may at least partially be explained by the reversal of scopolamine-induced reductions in brain antioxidant enzymes activity, inflammatory markers inhibition activity and acetylcholinesterase (AChE) inhibition activity by the both extracts.
Highlights
Alzheimer’s disease is a progressive neurodegenerative disease which is characterized by the loss of learning and memory abilities with aging
The study demonstrates the ability of the ethanolic extracts of E. alsinoides and C. asiatica to reverse scopolamine-induced learning and memory deficits in mice which may at least partially be explained by the reversal of scopolamine-induced reductions in brain antioxidant enzymes activity, inflammatory markers inhibition activity and acetylcholinesterase (AChE) inhibition activity by the both extracts
On 1st and 6th day and we found that there was no significant difference in Escape latency time (ELT) in all mice groups
Summary
Alzheimer’s disease is a progressive neurodegenerative disease which is characterized by the loss of learning and memory abilities with aging. This impairment of memory is correlated with the loss of cholinergic neurons. Scopolamine-induced amnesic animal models are used to screen for drugs that potentially have anti-dementia activities by stimulating the cholinergic system, make them a candidate for the treatment of Alzheimer’s disease. The Indian system of medicine describe a group of medicinal plants under the category of ‘Medhya Rasayana’, which possess the memory-enhancing effect and facilitate learning acquisition. Medicinal plants are rich sources of important metabolites, which are potential sources of antioxidant, antimicrobial, anti-inflammatory, and anticancer The utilization of herbal medicine in treating infectious diseases have been practiced for 1000s of years and will continue to provide mankind with new remedies [4]
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