Abstract
It has been over fifty years since the development of monoamine reuptake inhibitor antidepressants, that are widely prescribed and are the medication of choice for the treatment of depressive disorders. Although these agents have been useful, they also have significant limitations, including slow onset of action (weeks to months) and low rates of efficacy (approximately one third of patients respond to initial treatments). Thus, there is a significant unmet need for more effective, rapid-acting agents that have novel mechanisms. Here we discuss a few selected new areas of drug development and targets that are based on the combination of neurobiological research and clinical findings. This work holds promise for the development of new rapid-acting agents that may enhance the pharmacological armament for the treatment of depression.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
