Neuro-ophthalmological symptoms of intracranial dural arteriovenous fistulas

Abstract

The study objective was to identify the main neuro-ophthalmological symptoms of intracranial dural arteriovenous fistulas (dAVFs) with different localization, based on clinical and angiographic correlations. We analyzed neuro-ophthalmological symptoms in 272 patients with dAVFs verified by direct angiographic examination. The localization of dAVFs was as follows: the cavernous sinus (CS) - 143 patients, the lateral sinuses (LSs) and the confluence of sinuses - 77 patients, and other locations - 52 patients. Neuro-ophthalmological symptoms were detected in 163 (60%) patients. The symptoms were most typical of fistulas located in the CS (99% of patients with CS dAVFs). Neuro-ophthalmological symptoms were less typical of fistulas located in the LS and confluence (21% of patients with LS dAVFs) and dAVFs located outside of the CS and LS (9.6% of patients). Two main neuro-ophthalmological syndromes of intracranial dAVFs were identified: syndrome of obstructed venous outflow from the orbit and syndrome of intracranial hypertension (ICH). A correlation between neuro-ophthalmological symptoms and changes in the cerebral venous hemodynamics was found. The syndrome of obstructed venous outflow from the orbit is pathognomonic for CS dAVFs. In some cases, obstruction of venous outflow from the orbit was observed in patients with dAVFs of other localization, with involvement of the CS and orbital veins in drainage of the fistula. The ICH syndrome reflects the most significant obstruction of venous outflow from the cranial cavity, which is characteristic of LS dAVFs with retrograde outflow in the sinuses and cerebral veins.