Abstract
Purpose We aimed to find the possible key targets of Yougui pill and Buzhong Yiqi decoction for the treatment of sexual dysfunction. Materials and Methods The composition of Yougui pill combined with Buzhong Yiqi decoction was obtained, and its effective components of medicine were screened using ADME; the component target proteins were predicted and screened based on the TCMSP and BATMAN databases. Target proteins were cross-validated using the CTD database. We performed gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses for target proteins using the Cytoscape plugin ClueGO + CluePedia and the R package clusterProfiler, respectively. Subsequently, protein-protein interaction (PPI) analyses were conducted using the STRING database. Finally, a pharmacological network was constructed. Results The pharmacological network contained 89 nodes and 176 relation pairs. Among these nodes, there were 12 for herbal medicines (orange peel, licorice, Eucommia, Aconite, Astragalus, Chinese wolfberry, yam, dodder seed, ginseng, Cornus officinalis, Rehmannia, and Angelica), 9 for chemical components (18-beta-glycyrrhetinic acid, carvacrol, glycyrrhetinic acid, higenamine, nobilin, quercetin, stigmasterol, synephrine, and thymol), 62 for target proteins (e.g., NR3C1, ESR1, PTGS2, CAT, TNF, INS, and TP53), and 6 for pathways (MAPK signaling pathway, proteoglycans in cancer, dopaminergic synapse, thyroid hormone signaling pathway, cAMP signaling pathway, and neuroactive ligand-receptor interaction). Conclusion NR3C1, ESR1, PTGS2, CAT, TNF, INS, and TP53 may be important targets for the key active elements in the decoction combining Yougui pill and Buzhong Yiqi. Furthermore, these target proteins are relevant to the treatment of sexual dysfunction, probably via pathways associated with cancer and signal transduction.
Highlights
Sexual dysfunction is difficulty experienced by a couple or an individual during any stage of a normal sexual activity [1]
It is reported that the sexual dysfunction included orgasm disorders, arousal disorders, and interest or desire disorders [2]. e two most common male sexual dysfunctions are premature ejaculation and erectile dysfunction [3]
The composition of Yougui pill combined with Buzhong Yiqi decoction was obtained. e effective components of medicine were screened, and component target proteins were predicted and screened. en, target proteins were cross-validated, and the gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses for target proteins were conducted
Summary
Sexual dysfunction is difficulty experienced by a couple or an individual during any stage of a normal sexual activity [1]. E two most common male sexual dysfunctions are premature ejaculation and erectile dysfunction [3]. Premature ejaculation is ejaculation earlier than desired and with minimal stimulation [5]. In both men and women, factors including diabetes mellitus, age, general health, cardiovascular disease, other chronic health problems, and urinary tract infections play significant roles in the development of sexual dysfunction [2]. About 5% to 20% of men suffer from moderate to severe erectile dysfunction [6], and the prevalence rate of premature ejaculation is 20% to 30% [7]. Sexual dysfunction has severe adverse effects on patient’s quality of life, such as marital discord, loss of selfesteem and self-confidence, anxiety, and poor self-image [8], and effective clinical treatments for sexual dysfunction are necessary
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