Abstract
Background As a traditional Chinese medicine tonic, Buzhong Yiqi decoction has the effects of invigorating Qi and lifting Yang. In this study, the effects of Buzhong Yiqi Shenge decoction combined with THP bladder perfusion on postoperative efficacy in bladder cancer were investigated. Methods A total of 70 cases of bladder cancer patients were divided into the experimental group and control group according to the random number table method, with 35 cases in each group. The control group was treated with THP bladder perfusion. The experimental group was treated with Buzhong Yiqi Shenge decoction on the basis of the control group. The number of urine white blood cells, VEGF level, the incidence of adverse reactions, and KPS score were compared between the two groups before and after treatment. Results After 3 and 6 months of therapy, the KPS score of the experimental group increased significantly compared with the control group. However, after 12 months of treatment, there was no difference in KPS scores between the two groups. Moreover, there was no significant variation in serum VEGF between two groups after 3 months of treatment. However, Buzhong Yiqi decoction notably reduced the level of VEGF after 6 months and 12 months. After 3 months, the urine white blood cell count was lower in the experimental group than in the control group. After 6 and 12 months, there was no difference in urine white blood cell count between the two groups. Furthermore, a total of 14 patients in two groups had reoccurrence after one year. Our results showed that there was no significant difference in postoperative recurrence rate between the experimental group and the control group. The occurrence rates of frequent and urgent urination, nausea/loss, and abnormal urine routine of appetite in the experimental group were significantly lower than those in the control group. But there was no difference in the occurrence rate of low heat, hematuria between the experimental group and the control group. Conclusion Buzhong Yiqi decoction combined with THP bladder perfusion has no advantage in the short-term recurrence rate of bladder cancer patients. However, Buzhong Yiqi decoction can alleviate the symptoms of adverse reactions and improve the quality of life of patients.
Highlights
Bladder cancer is a malignant tumor arising from bladder epithelium and stroma
All patients were newly diagnosed with bladder cancer by biopsy and postoperative pathology. e diagnostic criteria were according to the Chinese Guidelines for the Diagnosis and Treatment of Urological Diseases in 2014. ese patients were randomly divided into the control group and experimental group. e control group was treated with THP bladder perfusion. e experimental group received Buzhong Yiqi Shenge decoction on the basis of the control group. ere was no statistical significance in age, gender, pathological grade, and clinical stage between the two groups (Table 1)
2 cases were lost during follow-up, and 1 case could not be reexamined on time
Summary
Bladder cancer is a malignant tumor arising from bladder epithelium and stroma. Bladder cancer is a common tumor of the urinary system, and its morbidity and mortality rank at the forefront of malignant tumors [1]. The effects of Buzhong Yiqi Shenge decoction combined with THP bladder perfusion on postoperative efficacy in bladder cancer were investigated. A total of 70 cases of bladder cancer patients were divided into the experimental group and control group according to the random number table method, with 35 cases in each group. E experimental group was treated with Buzhong Yiqi Shenge decoction on the basis of the control group. After 3 months, the urine white blood cell count was lower in the experimental group than in the control group. Our results showed that there was no significant difference in postoperative recurrence rate between the experimental group and the control group. Buzhong Yiqi decoction combined with THP bladder perfusion has no advantage in the short-term recurrence rate of bladder cancer patients. Buzhong Yiqi decoction can alleviate the symptoms of adverse reactions and improve the quality of life of patients
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