Abstract
In acute carbon monoxide poisoning the action of carbon monoxide on living organism has not been recognized to be explained satisfactory on the basis of oxygen lack alone, and thus some factors which might explain the essential properties of carbon monoxide poisoning have been assumed and investigated. We have found a factor by examining animals exposed to carbon monoxide biochemically and pharma-cologically. The factor in acute carbon monoxide poisoning was the velocity of carboxy-hemoglobin formation, but not carboxyhemoglobin formation in itself. This factor may be named as the inner circumstance factor corresponding to the outer circum-stance factor. This factor may also be considered to have some important roles not only in carbon monoxide poisoning but also in other many poisonings.
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