Abstract
Skin is the interface between the external environment and our body systems. It receives extensive innervation from the peripheral nervous system (PNS), which enables the skin to sense and respond to various stimuli such as touch and temperature. Recent studies have revealed unanticipated functions of cutaneous nerves in orchestrating stem cell behaviors and tissue regeneration. Diverse types of nerve fibers interact closely with different stem cell populations in the skin, specifying a nerve-derived niche for stem cell regulation. Here, we review recent discoveries on the nerve-stem cell crosstalk from tissue morphogenesis to regeneration and diseases, highlighting a key role of peripheral nerves in coupling stem cell activities with fluctuations from the inner body and the external world.
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