Nerve Conduction Studies (NCS) and Electromyography (EMG) P-NE002. The differences of vitamin D supplementation in nerve conduction studies based on diabetic duration and glycemic control in diabetic neuropathy

Abstract

Introduction. Diabetic neuropathy (DN) is the most common form of neuropathy in developed countries. Diabetic duration and glycemic control are risk factors for DN. Evidence that vitamin D can improve glycemic control is still uncertain. In some literatures, there are conflicting reports on the effect of vitamin D on nerve conduction studies (NCSs). Aim: To assess the differences of vitamin D supplementation in NCSs based on diabetic duration and glycemic control in type 2 diabetes mellitus (T2DM) Indonesian patients. Methods. Twenty-five subjects with T2DM in Haji Adam Malik General Hospital Medan were studied. They were treated for 10 weeks with vitamin D (D3) supplementation of 50,000 IU/week. They were evaluated by HbA1c level and routine NCSs in the upper and lower limbs, before and 10 weeks after vitamin D supplementation. The differences of vitamin D supplementation in NCSs were based on diabetic duration and glycemic control. This was analyzed with dependent t-test. Results. There were significant differences of vitamin D supplementation in distal latency (DL) of all nerves, and amplitude (A) of motor median, ulnar, peroneal, and tibial nerves and sensory sural nerve based on diabetic duration. There were significant differences in A of motor and sensory median and ulnar nerves and motor peroneal and tibial nerves, and nerve conduction velocity (NCV) of all nerves. Conclusion. There were differences in vitamin D supplementation in NCSs based on diabetic duration and glycemic control in T2DM Indonesian patients.