Abstract

Lasalocid (X-537A) is a polyether ionophore compound (Westly et al., 1970) that was isolated from streptomyces lasaliensis in 1951 (Berger et al., 1951). It is a lipid-soluble material which facilitates the passage of divalent and monovalent ions through lipophilic-biological membranes (Westley, 1977; Reed, 1982; Aebi. 1989). Lasalocid is used as a broad-spectrum anticoccidial agent and has been approved for use as a coccidiostat for chickens, and as a growth promoter for cattle (Bergen et al., 1984). However, lasalocid residues in commercial food were found to cause a paralytic syndrome in dogs (Safran et al., 1993a) and overdose in poultry feed caused neuromuscular deficit in chickens (Perelman et al., 1986).KeywordsGlial Fibrillary Acidic ProteinHippocampal NeuronNeuron Specific EnolaseHippocampal CultureArachidonic Acid ReleaseThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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