Abstract
After 12–14 weeks of administration of 2‐aminoanthraquinone at a level of 2% in the diet to Fischer F344 rats, female rats showed weight loss, alopecia, emaciation, ataxta, and finally, convulsions prior to death or sacrifice. Hematological studies in females revealed a depression of hematocrit values and a decline in hemoglobin and erythrocyte count, while both males and females showed an elevation of total leukocytes. In both sexes blood glucose concentration was increased and serum potassium levels were markedly elevated. In female rats blood urea nitrogen values were greatly increased. Histopathologically, females showed plugging of renal medullary and cortical tubules with yellow‐brown crystals, frequently accompanied by metaplasia of tubular epithelial cells, multinucleated giant cells, marked Interstitial fibrosis, and round cell infiltration. The bone marrow was hypoplastic. The primary toxicity of 2‐aminoanthraquinone appears to result in renal uremia, foci of tubular metaplasia, and hypoplasla o...
Published Version
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