Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat

Abstract

Acute kidney injury (AKI) with all advances in nursing measures and therapeutic strategies, such as kidney transplantation and dialysis, mortality rate of patients with AKI is very high in past 30 years. Despite the path physiology of IRI is not totally understood, several critical mechanisms leading in kidney failure have been demonstrated. In ischemic kidney and successive of generation of reactive oxygen species (ROS), re-oxygenation at reperfusion phase activate a cascade of destroying cellular responses causing to cell death, inflammation, and acute kidney failure. Sacubitrilate is neprilysininhibitor attenuated renal injury possibly through its anti-inflammatory and antioxidant effects. The main objective of the present paper is to study the potential effect of Sacubitrilate in RIRI. Renal IRI causes significant (p<0.05) increase in tissue level of IL-1β, NGAL, f2- isoprostane, TLR-4 and NF-KB p65 and serum urea, creatinine. Pretreatment with, Sacubitrilate cause significant (p<0.05) decrease in tissue level of IL-1β, NF-KB p65, TLR-4, NGAL, f2- isoprostane, and serum urea, creatinine. Also cause significant reversal of tissue damage when compared with IRI group. Pretreatment with Sacubitrilate significantly decreases renal ischemia reperfusion injury in the rat via their pleiotropic effects as antioxidant, anti-inflammatory and anti- apoptotic activity. How to Cite this Article Pubmed Style Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. SRP. 2019; 10(1): 194-205. doi:10.5530/srp.2019.1.35 Web Style Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. http://www.sysrevpharm.org/?mno=302644973 [Access: March 29, 2021]. doi:10.5530/srp.2019.1.35 AMA (American Medical Association) Style Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. SRP. 2019; 10(1): 194-205. doi:10.5530/srp.2019.1.35 Vancouver/ICMJE Style Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. SRP. (2019), [cited March 29, 2021]; 10(1): 194-205. doi:10.5530/srp.2019.1.35 Harvard Style Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin (2019) Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. SRP, 10 (1), 194-205. doi:10.5530/srp.2019.1.35 Turabian Style Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. 2019. Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Reviews in Pharmacy, 10 (1), 194-205. doi:10.5530/srp.2019.1.35 Chicago Style Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. Systematic Reviews in Pharmacy 10 (2019), 194-205. doi:10.5530/srp.2019.1.35 MLA (The Modern Language Association) Style Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin. Nephroprotective Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Rat. Systematic Reviews in Pharmacy 10.1 (2019), 194-205. Print. doi:10.5530/srp.2019.1.35 APA (American Psychological Association) Style Alaa Kadhum Mosa , Basem I. Mohammad Al-Shibani , Mohammed A. Abdulhussein , Najah R. Hadi , Hyder Qassam , Yasmeen Ali Hussin (2019) Potential Effect of Sacubitrilate in Renal Ischemia Reperfusion Injury Role of NF-Kbpathway in Reviews in Pharmacy, 10 (1), 194-205. doi:10.5530/srp.2019.1.35