Nephroprotective effect of black tea extract on cadmium induced male Wistar rats

Abstract

Introduction and Aim Cadmium is an environmental pollutant and potential nepho-toxicant to humans. Increase in industrialization interruptions heavy metal pollution in the world. Heavy metal chemicals destruction of organ functions and disrupts physiological homeostasis. Only the chelation therapy that involve the remove the heavy metal. Our study was designed to resolve the nehro-protective possessions of tea beverage on experimentally persuaded cadmium toxicity in the renal of rats. Tea was given orally while cadmium was administered subcutaneously. Method: Adult rats were divided into four groups (n=6/group). One control group (normal saline), two cadmium chloride group (CdCl2, 1.0 mg/kg, b.wt; i.p), Three Black tea extract group (black tea extract, 2.5 gm tea leaf/dl of water that is 2.5% of aqueous BTE) and Cadmium chloride plus black tea extract group (cadmium chloride + BTE). Simultaneously for 21 days. Results: Supplementation of black tea remarkably improves kidney architecture of rats treated with cadmium chloride group. Conclusion: Black tea extract seems to be nephron-protective against cadmium induced oxidative stress.