Abstract
This study sought to investigate the protective potentials conferred by the polysaccharide extracted from red marine alga Falkenbergia rufolanosa (FRP) against methyl Thiophanate (MT)-induced oxidative injuries in kidney tissue. Therefore, adult wistar rats were divided in four groups: control; MT (700 mg/kg) injected intraperitoneally for 3 days; FRP (200 mg/kg) administrated via alimentation for 7 days followed by MT co-injection at the last 3 days and only FRP (200 mg/kg) administrated via alimentation for 7 days. Data revealed a significant perturbation in plasma biochemical and oxidative stress parameters associated with the Nephrology toxicity features. These results were confirmed by kidney his to-architecture consorted by detection of Bcl-2, IL-1beta, and P53 examined via immunohistochemistry revelation. Nevertheless, co-treatment with FRP regulated MT-induced Nephrology toxicity as shown by an improvement in kidney biochemical, histological and immunohistochemistry profiles. In conclusion, FRP could be considered as a good source of naturally occurring antioxidant and Nephrology protective agent.
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