Abstract
The selectin class of proteins plays an important role in the inflammatory response. These proteins, which bind saccharide ligands, facilitate the recruitment of leukocytes to the inflamed endothelium. The ring-opening metathesis polymerization (ROMP) has been used to generate synthetic multidentate ligands, which display multiple copies of sulfated saccharide residues. By altering the structure of the appended saccharide residues, multivalent ligands that selectively target one member of the selectin family, P-selectin, were created. The biological activities of materials prepared from the same monomer unit varied, depending on the method of polymer preparation. This result suggests that polymers containing more repeat elements exhibit higher selectin inhibitory activities.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.