Although it is known that the symptoms of rheumatoid arthritis patients increase in cold, humid and rainy days but its mechanism is unclear. It was aimed to investigate the effects on some inflammatory and oxidative stress markers in different weather conditions in rats. Some inflammatory, oxidant and antioxidant markers were measured in sera of healthy rats in sunny, cloudy and rainy days. The levels of reduced glutathione (GSH) and glutathione reductase (GR) were found to be lower in both cloudy and rainy days with respect to sunny days (p = 0.001 and 0.004 respectively). Similarly, α -glutathione-S-transferase levels were found to be lower on rainy days than on sunny days (p = 0.017). Malondialdehyde (MDA) was found to be higher (p = 0.044) in rainy days compared to sunny days. Nitric oxide (NO) and interleukin-1β (IL-1β) were found to be higher in cloudy and rainy days compared to sunny days (p = 0.003 and 0.025, respectively). The findings indicate that oxidative stress-related inflammation is triggered in rainy and cloudy days.

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