Abstract
Necroptosis DAMPens anti-tumor immunity.
Highlights
Pancreatic ductal adenocarcinoma (PDA) causes a highly lethal cancer and is predicted to become the second most common cause of cancer-related death by 2030.1 In 2012, the number of deaths due to pancreatic cancer was estimated to have reached 330 000 worldwide
KRAS is one of oncogenes frequently found in human pancreatic cancers and its expression was detected in pancreatic intraepithelial neoplasia (PanIN) lesions
In vitro experiments showed that deletion of RIP3 in pancreatic ductal epithelial cells from KRASG12D mice increased cell proliferation, which may suggest that RIP3 is required for tumor progression in vivo
Summary
Pancreatic ductal adenocarcinoma (PDA) causes a highly lethal cancer and is predicted to become the second most common cause of cancer-related death by 2030.1 In 2012, the number of deaths due to pancreatic cancer was estimated to have reached 330 000 worldwide. In vitro experiments showed that deletion of RIP3 in pancreatic ductal epithelial cells from KRASG12D mice increased cell proliferation, which may suggest that RIP3 is required for tumor progression in vivo. These results led the author to investigate the mechanism by which necrosome-mediated signaling regulates anti-tumor effects against oncogenic progression of PDA.
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