Abstract
ObjectiveTo evaluate the association between neck circumference (NC) and hyperuricemia in women with polycystic ovary syndrome (PCOS).MethodsThis is a cross-sectional study that recruited 601 women with PCOS from January 2018 to January 2021. PCOS was diagnosed according to the Rotterdam definition. Hyperuricemia was defined as serum uric acid level of at least 357 μmol/L.ResultsPCOS females with hyperuricemia had significantly greater values of NC, body mass index (BMI), waist circumference (WC) and hip circumference (HC). NC was positively associated with serum uric acid levels, with a standardized regression coefficient of 0.34 after adjusting for confounding factors. Furthermore, logistic regression analysis showed that NC was significantly associated with an increased risk of hyperuricemia, with an adjusted odds ratio of 1.36. The associations between NC and serum uric acid levels were more considerable in those with medium/high BMI (BMI ≥ 21.63 kg/m2), all ranges of WC or medium/high HC (HC ≥ 90 cm). The optimal cut-off point of NC in predicting hyperuricemia was 32.0 cm (Youden index = 0.48), with the sensitivity and negative predictive value of 84.81% and 92.08%, respectively.ConclusionsNC was positively correlated with serum uric acid levels and the prevalence of hyperuricemia in women with PCOS. Therefore, we suggest NC as a simple, novel, and reliable anthropometric measure to be used in the routine clinical assessment of women with PCOS to screen those at high risk of hyperuricemia.
Highlights
Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders in reproductive-aged individuals, with an incidence of 3%-20% according to different diagnostic criteria [1,2,3]
Uric acid is a metabolite produced during purine metabolism, and elevated serum uric acid levels have been demonstrated as a risk factor of metabolic disorders, including hypertension, diabetes and cardiovascular diseases [6]
There were no significant differences between the two groups in basal luteinizing hormone (LH) levels, E2 levels, anti-mullerian hormone (AMH), LH/follicle stimulating hormone (FSH) ratio, FBG or eGFR
Summary
Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders in reproductive-aged individuals, with an incidence of 3%-20% according to different diagnostic criteria [1,2,3]. In addition to the effect on metabolism, recent review suggests that there is a close relationship between serum levels of uric acid and female reproductive disorders [7]. It has been confirmed that BMI [12,13,14], waist circumference [15,16,17] and hip circumference are positively correlated with the risk of hyperuricemia in different populations. It is not always feasible and accurate to measure WC, HC and BMI in the winter with heavy clothes or postprandially. There is a need for a reliable, simple and fast method to identify hyperuricemia early in clinical practice
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