NECK CIRCUMFERENCE IS A GOOD PREDICTOR FOR HYPERURICEMIA IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

Abstract

To explore the correlation between neck circumference (NC) and serum uric acid level and assess the predictive value of NC for hyperuricemia in women with polycystic ovary syndrome (PCOS). One hundred and ninety women diagnosed with PCOS were recruited from January 2018 to December 2019. Anthropometric parameters, neck circumference, serum uric acid, reproductive hormones, glucose and lipids were measured in all subjects. PCOS females with hyperuricemia had significantly greater values of NC, body mass index (BMI), waist circumference (WC), hip circumference (HC), systolic blood pressure, diastolic blood pressure, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of β cell function (HOMA-β) and triglyceride. NC was positively and significantly associated with serum uric acid level (log-transformed), with a standardized regression coefficient of 0.34 after adjusting for potential confounding factors. Furthermore, logistic regression analysis showed that NC was significantly associated with increased risk of hyperuricemia, with an adjusted odds ratio of 1.58. Additionally, NC was able to identify hyperuricemia in women with PCOS. The optimal cut-off points were 32.0 cm (Youden index = 0.48). The sensitivity and negative predictive value of NC in predicting hyperuricemia was 87.23% and 93.68%, respectively. The area under the curve in predicting hyperuricemia by NC, BMI, waist circumference and hip circumference was comparable. There were significant interactions of NC with BMI, WC and HC. The associations between NC and serum uric acid level were more evident in those with medium BMI (22.02kg/m2 ≤ BMI < 25.08kg/m2), low WC (WC < 85 cm) or medium HC (90 cm ≤ HC < 96 cm). Neck circumference is positively correlated with hyperuricemia in women with PCOS. NC had the highest negative predictive value for hyperuricemia than BMI, WCand HC in women with PCOS. Therefore, we suggest NC as a simple, novel, and reliable anthropometric measure to be used in the routine clinical assessment of PCOS women to screen those at high risk of hyperuricemia.