Abstract
Background To investigate the relationship of the neck circumference (NC) with non-alcoholic fatty liver disease (NAFLD) in non-obese Chinese population.MethodsOur data were obtained from a cross-sectional survey on the prevalence of metabolic diseases and risk factors in East China in 2014. Subjects with a BMI ≥ 18.5 kg/m2 and < 25 kg/m2 were considered normal weight. A total of 2668 participants aged 18–89 were identified for analysis. Anthropometric indices, biochemical parameters, clinical characteristics and abdominal ultrasound were measured. Independent predictors of NAFLD were identified by multiple logistic regressions.ResultsThe overall prevalence of NAFLD was 10.94 % in this study population and men had a higher prevalence than women (19.89 % vs 7.48 %, P < 0.01). The mean NC was greater in NAFLD subjects compared with other groups in both genders (P < 0.01). NC was correlated to BMI, waist circumference, hip circumference, systolic blood pressure, diastolic blood pressure, insulin, HOMA-IR, triglycerides and ALT, regardless of sex. In the highest quartile of NC levels in men but not in women, the risks were substantially higher for NAFLD [odds ratio 2.18, (95 % confidence interval 1.16–4.13)] (P < 0.001 for trend) after adjusting for potential confounding factors.ConclusionNC was an independent indicator for NAFLD in normal weighted men.
Highlights
To investigate the relationship of the neck circumference (NC) with non-alcoholic fatty liver disease (NAFLD) in non-obese Chinese population
Mean age levels gradually increased from normal people to NAFLD subjects (P < 0.001), which was in agreement with previous
We showed that ALT, TG, NC levels and smoke status were independently and significantly associated with NAFLD in men
Summary
To investigate the relationship of the neck circumference (NC) with non-alcoholic fatty liver disease (NAFLD) in non-obese Chinese population. The distribution of body fat is an important factor that determines metabolic health [1]. The neck circumference (NC) measurement is a surrogate marker of determining upper-body subcutaneous distribution and the close correlations between NC and various metabolic risk factors have been widely explored [3,4,5]. Non-alcoholic fatty liver disease (NAFLD) has a close relationship with components of metabolic syndrome and is considered the hepatic manifestation of metabolic. NAFLD is characterized by ectopic fat deposition [10]. NC is an alternative measurement for upper-body subcutaneous fat and is a good indicator of ectopic fat distribution [4, 11]. NC has been proposed as an effective predictor for NAFLD in the general
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