Abstract
Summary Fifteen children who were admitted to hospital with a severe asthmatic attack, refractory to oral bronchodilators, were treated initially with an oxygen-propelled nebulized 0,5 % solution of salbutamol. Significant clinical improvement occurred rapidly in fourteen of these children. There was a significant decrease in their specific airway resistance (SRaw) 1 min after the end of the nebulization and this decrease was still present 1 hour later. Significant improvement of forced expiratory volume (FEV1), forced vital capacity (FVC) and peak expiratory flow rate (PEFR) paralleled the decrease in SRaw. Increased heart rate occured but was not perceived by the children. Transcutaneous arterial O2 tension (TcPaO2) was increased in thirteen children and unchanged in two of them 10 min after the nebulization. These results demonstrate that nebulized salbutamol is safe and highly effective in the treatment of severe asthmatic attacks in children.
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