Abstract
A case of Philadelphia chromosome positive chronic myeloid leukemia is reported in which the patient developed a near-haploid cell line during blast transformation. Although there was only one copy of most chromosomes, two copies of chromosomes 8, X, and 21 were present and the significance of this is discussed. It is postulated that a haploid event rather than chromosome loss was responsible for this. It was not associated with a particularly aggressive course of the disease. The relationship between the near-haploidy and cellular morphology is examined.
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