Abstract
Near‐infrared (NIR) light‐responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial organ or tissue (e.g., skin). This work describes the development of NIR‐responsive liposomes by incorporating gold nanostars within liposomes composed of Phospholipon 90 g and cholesterol. Following cellular delivery, photothermal effect around the gold nanostar upon NIR stimulation induces microcavitation and liposome phase transition which consequently triggers the release of encapsulated molecules. Taking GFP plasmid as an example, we demonstrate enhanced gene transfection into fibroblasts following NIR treatment.
Highlights
Light-responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial tissues and organs
The longest period of 96 hr was observed for liposomes composing of phospolipon 90G (P90G) and Cho with ratio of 7:28
We report the construction of NIR-responsive liposomes with AuNSs
Summary
Light-responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial tissues and organs (e.g., skin). To accommodate the optical window of biological tissues, liposomes sensitive to near-infrared (NIR) lights (650–900 nm) are preferred.[1,2] A convenient way to synthesize such liposomes is to incorporate photosensitizing components within thermal-responsive liposomes. Bioengineering & Translational Medicine is published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers.
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