Abstract
In the present article we report the nearly full length genome of a Cosavirus strain (BRTO-83) isolated from a child with acute gastroenteritis, and who is an inhabitant of a rural area in the central region of Brazil. The sample was previously screened and negative for both: common enteric viruses (i.e. rotavirus and norovirus), bacteria, endoparasites and helminthes. Evolutionary analysis and phylogenetic inferences indicated that the Brazilian BRTO-83 Cosavirus strain was a recombinant virus highly related to the E/D recombinant NG385 strain (Genbank JN867757), which was isolated in Nigeria from an acute flaccid paralysis patient. This is the first report of a recombinant E/D Cosavirus strain detected in Brazil, and the second genome described worldwide. Further surveillance and molecular studies are required to fully understand the epidemiology, distribution and evolution of the Cosavirus.
Highlights
In the present article we report the nearly full length genome of a Cosavirus strain (BRTO-83) isolated from a child with acute gastroenteritis, and who is an inhabitant of a rural area in the central region of Brazil
We report the detection of a recombinant Cosavirus strain (BRTO-83) isolated from a fecal sample obtained from a 1-year-old-child patient presenting acute gastroenteritis in 2013, in the state of Tocantins, Central Brazil
Fecal specimens were screened for enteric viruses, bacteria (i.e E. coli and Salmonella sp.), endoparasites (i.e. Giardia sp.) and helminthes using conventional and molecular methods
Summary
A survey conducted throughout in the northern state of Tocantins in Brazil was performed during the years 2010 through 2016 to screen human feces for the presence of enteric pathogens. Recombination analysis indicated that the first 2680 bases of the BRTO-83 genome are related to the genotype E, while the remaining nucleotides are related to the genotype D (Fig. 2 and Supplementary data). This pattern of Cosavirus recombination has been previously reported only once, in 2007, from a Nigerian patient suffering from AFP (NG385 strain; JN867757). In Brazil, there is only one study considering Cosaviruses role; its association with gastroenteritis could not be established[3] This is the first report of a recombinant E/D Cosavirus strain detected in Brazil, and the second genome described worldwide. Further surveillance and molecular studies are required to fully understand the epidemiology, distribution and evolution of the Cosavirus
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