Nd:YAG laser vs IPL in inflammatory and noninflammatory acne lesion treatment.

Abstract

Several topical and systemic therapies are available for the treatment of acne vulgaris but are associated with several limitations, and recently, intense pulse light (IPL) and long-pulsed 1064nm Nd: YAG laser have shown efficacy. The current study aimed to compare the efficacy of Nd:YAG laser and IPL in inflammatory and noninflammatory acne lesions. Thirty patients with inflammatory and noninflammatory facial acne were assigned randomly and equally into two groups, the Nd:YAG and IPL groups. The patients received three sessions of laser 2weeks apart, and the clinical improvement was assessed by the reduction in the number of lesions. At baseline, the two groups showed a nonsignificant difference as regards total number (P=.476), inflammatory (P=.457), and noninflammatory lesions (P=.420). The improvement in total lesions was significant in the Nd:YAG Group but nonsignificant in the IPL Group (P<.001, P=.13, respectively). Three patients (20%) in the IPL Group showed exacerbation after the first and second sessions. One month after the last session, the difference in improvement between noninflammatory and inflammatory lesions showed a significant difference in the Nd:YAG Group (P=.017) and a nonsignificant difference in the IPL Group (P=.823). Nd:YAG, compared to the IPL Group, showed a significant difference as regards the improvement score in noninflammatory lesions (P=.0099) and a nonsignificant difference in inflammatory lesions (P=.4295). The significant improvement in noninflammatory lesions and the absence of a significant flare-up of acne as seen among patients treated with IPL make Nd:YAG a better therapeutic modality for acne.