Navigating TRPML1 Scholarly Hotspots Through a Bibliometric Lens

Abstract

Transient Receptor Potential Mucolipin 1 (TRPML1) is a calcium-permeable cation channel predominantly localised on late endosomes and lysosomes. Its multifaceted roles encompass lysosomal exocytosis, autophagy, and cellular processes, such as mitochondrial function and cancer cell invasion. Despite extensive research on TRPML1, there remains a need to systematically evaluate TRPML1-related studies for the scientific community. Our goals were to analyse TRPML1 research publications to pinpoint key contributors, trends, and major themes. The aim is to showcase significant discoveries and untapped areas within TRPML1 for future research endeavours. In this study, we employed bibliometric tools, specifically VOSviewer, to quantitatively analyse TRPML1 publications. TRPML1 research witnessed an upward trajectory, peaking in 2019. The United States emerged as the predominant contributor, with China gaining prominence in recent years. The Journal of Biological Chemistry stood out as a leading disseminator of TRPML1-related findings. Additionally, Nature and Nature Communications boasted the highest citation rates, emphasising the impact of TRPML1 research. Highly cited articles unravelled TRPML1's pivotal role in iron homeostasis and autophagy regulation, shaping scholarly discourse and therapeutic advancements. Author networks spotlighted influential contributors such as Haoxing Xu, and Susan A Slaugenhaupt. Keyword analysis identified clusters related to lysosomal disorders, cellular regulations, and cellular stress, providing insights into prevailing research priorities. Initially, TRPML1 research centered on understanding its role in endosomes and lysosomes, revealing its relevance in various physiological and pathological conditions. However, certain underexplored research avenues for TRPML1 deserve attention, particularly in the context of autophagy and cancer. Finally, this study explored seven key research frontiers of TRPML1, illuminating critical areas namely podocyte function, exosome release, neurodegeneration, autophagy regulation, cancer progression, apoptosis, and interactions with reactive oxygen species. By delving deeper into these domains, researchers can enhance their understanding of TRPML1 and potentially open avenues for innovative disease interventions.