Abstract
PurposeTo examine whether personal history of nausea or history of nausea and vomiting of pregnancy (NVP) in relatives are risk factors for a woman to suffer from NVP. Further, to evaluate if these factors are associated with the severity of NVP.MethodsCohort study of 2411 pregnant women recruited from maternity health care clinics. The severity of NVP was categorized according to Pregnancy-Unique Quantification of Emesis (PUQE) questionnaire into no/mild/moderate/severe NVP. History of nausea was assessed in connection with motion sickness, seasickness, migraine or other kinds of headache, after anesthesia, related to the use of contraceptives, and other kinds of nausea. History of NVP in relatives was categorized into first-degree (mother/sister) and second-degree relatives (more distant).ResultsIn multivariable analysis including previous personal history of nausea, motion sickness (OR 3.17, 95% CI 1.81–5.56, p < 0.0001) and nausea in migraine (OR 3.18, 95% CI 1.86–5.45, p < 0.0001) were associated with severe NVP. History of nausea in other kinds of headache was associated with moderate NVP (OR 1.91, 95% CI 1.34–2.72, p = 0.001). Women with affected first-degree relatives had higher odds for moderate (OR 3.84, 95% CI 2.72–5.40) and severe (OR 3.19, 95% CI 1.92–5.28) NVP (p < 0.0001). All these results remained significant after adjusting for parity, body mass index, smoking, employment and age.ConclusionWomen with personal history of nausea or family history of NVP have an increased susceptibility of NVP. This information is useful in pre-pregnancy counselling.
Highlights
Nausea and vomiting of pregnancy (NVP) affect up to 80% of women in early pregnancy [1]
88% of 2381 women suffered from NVP
From the entire study cohort, 47.0% (n = 1091) of women suffered from motion sickness, 32.1% (n = 731) had seasickness, 30.2% (n = 687) had migraine, 40.1% (n = 904) had history of other kind of headache and 12.5% (n = 262) had history of nausea after anesthesia
Summary
Nausea and vomiting of pregnancy (NVP) affect up to 80% of women in early pregnancy [1]. Etiology of nausea in general [4] seems to be multifactorial, and the same applies for the etiology of NVP [5, 6]. Many women experience nausea and vomiting in connection with motion sickness, seasickness, migraine or other kind of headache [7,8,9,10]. Nausea and vomiting are reported in relation to the use of oral contraceptives and after anesthesia [11, 12]. Mechanisms behind both general nausea and NVP involve vestibular, olfactory, hormonal and gastrointestinal
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