Abstract
We detected 2 natural, asymptomatic Plasmodium inui monoinfections in humans in Malaysia by using nested PCR on concentrated high-volume blood samples. We found a P. inui–positive Anopheles cracens mosquito in the same site as the human infections. Investigators should use ultrasensitive detection methods to identify simian malaria parasite transmission in humans.
Highlights
We detected 2 natural, asymptomatic Plasmodium inui monoinfections in humans in Malaysia by using nested PCR on concentrated high-volume blood samples
Among the 3 simian malaria parasites in Southeast Asia experimentally shown to infect humans [1], Plasmodium knowlesi, P. cynomolgi, and P. inui, only P. knowlesi and P. cynomolgi have been reported in cases of natural infection [2]
We report 2 natural, asymptomatic P. inui human infections detected by using nested PCR on concentrated high-volume blood
Summary
We detected 2 natural, asymptomatic Plasmodium inui monoinfections in humans in Malaysia by using nested PCR on concentrated high-volume blood samples. Among the 3 simian malaria parasites in Southeast Asia experimentally shown to infect humans [1], Plasmodium knowlesi, P. cynomolgi, and P. inui, only P. knowlesi and P. cynomolgi have been reported in cases of natural infection [2]. We report 2 natural, asymptomatic P. inui human infections detected by using nested PCR (nPCR) on concentrated high-volume blood.
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