Abstract
In order to create a new sustained drug delivery system applied for tissue regeneration, this study beget a natural rubber latex (NRL) film with Casearia sylvestris extract and ciprofloxacin. Manipulated from the biomaterial latex obtained by the rubber tree Hevea brasiliensis , the NRL film has shown to be a great angiogenic compound and also has shown a great potential in being a possible carrier for sustained drug release. In order to increase the therapeutic spectrum of the film two substances was added to it: the C. sylvestris extract which has antiulcer, anti-inflammatory and Original Research Article
Highlights
Nowadays, some terms like “sustained release and the drug delivery systems” has come to evidence in the pharmacology field
In order to create a new sustained drug delivery system applied for tissue regeneration, this study beget a natural rubber latex (NRL) film with Casearia sylvestris extract and ciprofloxacin
First this study propose to evaluate the interaction of the extract of C. sylvestris along to the ciprofloxacin in NRL films, understand their sustained release behavior to analyze if the aggregation is possible
Summary
Some terms like “sustained release and the drug delivery systems” has come to evidence in the pharmacology field. The main reason of this is because pharmacological substances when applied in a conventional manner, as orally for example, take too much time to reach the site in which they are needed and hardly achieves it under the appropriate concentrations to cause the expected therapeutic effect [1,2] This fact is justified because there are numerous obstacles in the body, such as anatomical and chemical barriers between the place of administration of the drug and its final target. The latex from the rubber tree Hevea brasiliensis has shown to be a biocompatible material with good qualities to serve as a potential base for a drug delivery system It has shown numerous biomedical applications, along with high mechanical strength and low cost, making it useful in medicine. Alves et al [4] showed that the latex has the property of accelerating angiogenesis, it means, the growth of blood vessels, important characteristic in a tissue regeneration field
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