Abstract
Object: We aimed to show the relationship between natural killer T and natural killer cells with the diseases activity and functional capacity, in the patient with rheumatoid arthritis and ankylosing spondylitis. Materials and Methods: All patients included in the study were evaluated to the disease activity and functional capacity and radiographic view and also; their’ blood count and C- reactive protein, erythrocyte sedimentation rate and rheumatoid factor and natural killer T and natural killer cells were measured, simultaneously. Results: It was shown to be the positive correlation between the disease activity with total Sharp score and functional capacity. Significant positive correlation was found the between BASDAI score with natural killer T cells. The ratio of natural killer T and natural killer cells was found higher, using of the methotrexate treatments with rheumatoid arthritis patients. No correlation was found the between percentage of natural killer T and natural killer cells with using of the methotrexate treatment, in the patients with ankylosing spondylitis. Conclusion: Determination of the levels of natural killer T and natural killer cells can contribute to estimation of the disease course and treatment response and the development of functional disorders, in the patients with rheumatoid arthritis and ankylosing spondylitis.
Highlights
Rheumatoid arthritis (RA) is a chronic inflammatory and autoimmune disease
natural killer cells (NK) and natural killer T cells (NKT) cells contribute to the cytokines production and development of antibodydependent cellular cytotoxicity (ADCC).Currently; it is suggested to that NK and NKT cells [4] have protective and pathogenic role as a direct and indirect, the development of rheumatoid arthritis
We aimed to show the existence of the association between percentage of NK and NKT cells in the peripheral blood with the disease activity and functional capacity and using treatment, under the regularly follow-up and treatment in the patients with RA and Ankylosing spondylitis (AS)
Summary
Rheumatoid arthritis (RA) is a chronic inflammatory and autoimmune disease. Joint inflammation and bone destruction are the important features of RA. It is known, the development of rheumatoid arthritis disease[1] can contribute to the interaction between genetic and environmental factors. NK and NKT cells [3]constitute of lymphocytes population and they have the immune regulatory role. NK and NKT cells contribute to the cytokines production and development of antibodydependent cellular cytotoxicity (ADCC).Currently; it is suggested to that NK and NKT cells [4] have protective and pathogenic role as a direct and indirect, the development of rheumatoid arthritis
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