Natural Anti-Aging Formulations with UV/Photo-Protective Potential Containing Plant Derived Oils

Abstract

Topical natural oil-based anti-aging o/w emulsions with UV protection capability were developed with the help of sesame (F1), black cumin (F2), flax (F3), and poppy seed oil (F4) and their combination(F5) having comparable SPF and antioxidant activities and their values were calculated using UV spectrophotometer and DPPH scavenging test respectively. Five separate formulations of all oils were made and stored at various storage temperatures, including 8°C, 25°C, 40°C and 40°C ± 75% RH. These formulations were then examined for stability at their storage parameters which involved changes in color, odor, phase separation, pH, conductivity, centrifugation as well as spreadability for two months, with tests being conducted after a particular duration. According to the experimental findings, the antioxidant activity of sesame, black cumin, flax, and poppy seed oil is 63%, 59%, 72%, and 47%, respectively while the combination formulation showed 76% activity. On day 60th at 40°C ± 75%RH, the SPF values of F1, F2, F3, F4 & F5 were 2.53, 6.26, 8.11, 6.09, and 12.01 respectively. F1 and F2 displayed a white-to-yellowish color change on the 60th day at 40°C ± 75%RH. No formulations showed odor change. Phase separation was seen in F1 and F2 after two months at 40°C, while F3, F4, and F5 were stable and their spreadability also increased with time at an elevated condition while the pH of all five formulations tended to decrease. The study results provided evidence that combining essential oils produces effective outcomes without affecting the emulsion system stability.