Abstract
The renal response to an isotonic saline load was studied in dogs with a side-to-side superior mesenteric-caval shunt before and after hepatic inflow occlusion to determine if the liver influenced renal sodium excretion. During the control period, there was no difference between the eight sham-operated and eight experimental dogs. During the study period, the sham dogs, who only had manipulation of the hepatic artery and portal vein, had an increased urine flow rate and renal sodium excretion, while the experimental dogs with hepatic inflow occlusion had a statistically-in-significant decrease in renal sodium excretion. The change in filtered sodium from control to study periods was unrelated to the change in sodium excretion in the sham dogs but was directly related in the experimental dogs. When the difference from control to study periods was compared in sham and experimental dogs, there was a significant difference for urine flow rate, and fractional and total renal sodium excretion. Absence of the liver appears to influence renal sodium excretion and may be of significance for sodium retention with liver disease.
Published Version
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