Abstract
Sepsis is a syndrome with physiologic, pathologic, and biochemical abnormalities induced by infection. Sepsis can induce the dysregulation of systemic coagulation and fibrinolytic systems, resulting in disseminated intravascular coagulation (DIC), which is associated with a high mortality rate. Although there is no international consensus on available treatments for sepsis-induced DIC, DIC diagnosis and treatment are commonly performed in Japanese clinical settings. Therefore, clinical data related to sepsis-induced DIC diagnosis and treatment can be obtained from Japanese clinical settings. We performed a retrospective nationwide observational study (Japan Septic Disseminated Intravascular Coagulation [J-SEPTIC DIC] study) to collect data regarding characteristics of sepsis patients in Japan, with a focus on coagulofibrinolytic dysregulation and DIC treatment received by each patient. The J-SEPTIC DIC study collected information for a total of 3,195 patients with severe sepsis and septic shock and is the largest data set in Japan on DIC diagnosis and treatment in clinical settings.
Highlights
Background & SummarySepsis is a syndrome with physiologic, pathologic, and biochemical abnormalities induced by infection and resulting in life-threatening organ dysfunction[1,2]
A global epidemiological report estimated that 31.5 million people are affected by sepsis and 19.4 million people are affected by severe sepsis each year, with a potential 5.3 million deaths worldwide from sepsis each year[3]
In Japanese clinical settings, Disseminated intravascular coagulation (DIC) diagnosis using scoring systems are generalized in sepsis management[9]
Summary
Sepsis is a syndrome with physiologic, pathologic, and biochemical abnormalities induced by infection and resulting in life-threatening organ dysfunction[1,2]. Disseminated intravascular coagulation (DIC) is induced by the dysregulation of systemic coagulation and fibrinolytic systems in sepsis and septic shock[2,4,5]. Recombinant thrombomodulin, antithrombin and other anticoagulants are approved as DIC treatment drugs and are frequently used in patients with sepsis-induced DIC10,11. Clinical data related to the treatment of sepsisinduced DIC can be collected from clinical settings in Japan. We performed a retrospective nationwide observational study (Japan Septic Disseminated Intravascular Coagulation [J-SEPTIC DIC] study), which collected data on the characteristics of sepsis patients with a focus on coagulation dysregulation and DIC treatments. Previous studies on DIC treatment have been conducted using the J-SEPTIC DIC data set[12,13,14,15,16,17,18,19,20]
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