Abstract
Results More than one third (35%) of severe asthma patients, predominantly non-atopic (44%), reported CRSwNP (OR:3.4; p<0.001), and 30% AR (OR:1.03; NS). Aspirin sensitivity was associated with severe asthma (43%; OR:7.8; p<0.05) The presence of CRSwNP was also associated with AIA (38.9%; OR:9.05; p<0.001). Apart from high asthma symptom score, need of intense treatment, and exacerbation rate, patients with severe asthma were older (p<0.001), had late onset asthma (p<0.001), and showed higher sinus CT scores (p<0.001) which correlated with poor asthma control. Multiple logistic regression analysis showed that CRSwNP, AIA, and late onset asthma were independently associated with severe asthma.
Highlights
Recognition of severe asthma may improve its management, modify its natural history by better approaching therapy and helps identifying patients resistant to current asthma therapy
Aspirin sensitivity was associated with severe asthma (43%; OR:7.8; p
Apart from high asthma symptom score, need of intense treatment, and exacerbation rate, patients with severe asthma were older (p
Summary
Recognition of severe asthma may improve its management, modify its natural history by better approaching therapy and helps identifying patients resistant to current asthma therapy. Rhinitis and chronic rhinosinusitis are linked to asthma by clinical, epidemiological and similar inflammatory mechanisms which interrelates upper and lower airways. Evidence for high rate of chronic rhinosinusitis has been related to severe asthma
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