Abstract
Nasal NK/T cell lymphoma (NKTL), is an aggressive malignancy associated with Epstein Barr virus infection. Nasal NK/T cell lymphoma (NKTL), manifests as a necrotic process affecting nasal or upper aerodigestive structures and, rarely, extra nasal sites such as skin, and the gastrointestinal tract. The diagnosis is confirmed by histological and immunohistochemical analysis of the biopsy. Overall prognosis is poor. However, during the last two decades, advances in its clinicopathologic, genetic and molecular characterization have been achieved, as have changes in the chemotherapy regimens that, in combination with radiotherapy, are significantly improving the survival of these patients, especially in initial stages.
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