Abstract
Nasal Manifestations in Granulomatosis with Polyangiitis: A Case Report and Review of the Literature
Highlights
Granulomatosis with polyangiitis (GPA), previously known as Wegener granulomatosis, is an anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides of medium and small arteries, characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract with coexisting glomerulonephritis
We report a case of GPA in a patient presenting with a six-month history of spontaneous epistaxis, nasal obstruction and frontal headache and evidence at physical examination of a polypoid mass in the nasal fossae and an asymptomatic perforation of the nasal septum
A 38-year-old women presented to the Otolaryngology Department of our University reporting a six-month history of spontaneous epistaxis, nasal obstruction and frontal headache
Summary
Granulomatosis with polyangiitis (GPA), previously known as Wegener granulomatosis, is an anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides of medium and small arteries, characterized by necrotizing granulomatous inflammation of the upper (ear, nose, throat) and lower (lung) respiratory tract with coexisting glomerulonephritis (renal systems). We report a case of GPA in a patient presenting with a six-month history of spontaneous epistaxis, nasal obstruction and frontal headache and evidence at physical examination of a polypoid mass in the nasal fossae and an asymptomatic perforation of the nasal septum. A 38-year-old women presented to the Otolaryngology Department of our University reporting a six-month history of spontaneous epistaxis, nasal obstruction and frontal headache. Otolaryngologic physical examination through nasal endoscopy showed an anterior perforation of the nasal septum and a polypoid translucid mass in the anterior right nasal cavity. The patient performed maxillofacial computed tomography (CT) scan with contrast that confirmed the presence of a soft density polypoid mass occupying the anterior portion of right nasal fossa associated with cartilaginous nasal septum perforation (Figure 1). No signs of recurrence of the diseases were observed one year after surgery
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