Nar Kabuğu Polar Fraksiyonlarının ve Amoksisilin Trihidratın Enterococcus faecalis Üzerindeki Sinerjistik Etkisi Hakkında bir Çalışma

Ayşegül Hoş,Alican Bahadir Semerci̇,Hilal Kuday,Kenan Tunç

doi:10.33484/sinopfbd.634931

Abstract

The increase in the occurrence of the multidrug-resistant bacteria is the cause of need in the discovering new antimicrobial substances and antimicrobial combination drugs. The aim of this study was to investigate the synergistic interaction between polar fractions of pomegranate (Punica granatum L.) peel and Amoxicillin trihydrate against Enterococcus faecalis. In the first step of the study, polar fractions of pomegranate peel (ethyl acetate, butanol, distilled water) were prepared. Next, disc diffusion method was used for determination of the synergic effect. Here, the results indicated that the mixture of prepared polar fractions of pomegranate peel and Amoxicillin trihydrate showed synergistic interaction against E. faecalis. This study determined that polar fractions of pomegranate peel (ethyl acetate, butanol, distilled water) improved the effectiveness of Amoxicillin trihydrate against E. faecalis. Pomegranate peel may have potential applications in the new antibacterial therapy combinations due to its easy accessibility, therapeutic properties and being low cost. Results of the present study may be beneficial for further studies about the characterization of phytochemical compounds that are responsible for the improvement of the antibiotic effectiveness.

Highlights

The multiple antibiotic resistance of pathogen microorganisms is a serious medical problem
The synergistic interaction between polar fractions of pomegranate peel and Amoxicillin trihydrate against E. faecalis were investigated in this study
No study has not been found about the synergistic interaction between polar fractions of pomegranate peel and Amoxicillin trihydrate

Summary

Introduction

The multiple antibiotic resistance of pathogen microorganisms is a serious medical problem. The improving of antibiotic efficacy has a great importance. 25% of drugs prescribed worldwide are plant origin [1]. Antimicrobial compounds derived from plants have been found to be synergistic enhancers. They may not possess any antimicrobial properties alone, they enhance the activity of the drugs when used concurrently with standard drugs [2]. Many different cultural healing systems rely on the combination therapy that enhanced the efficacy. The combination may enhance efficacy, reduce toxicity, decrease adverse side effects, increase bioavailability, lower the dose and reduce the advance of antimicrobial resistance. Investigation of antimicrobial combination drugs have become priority [3]

Objectives

Methods

Results

Conclusion