Abstract
The metabolites of the genus Marasmius are diverse, showing good research prospects for finding new bioactive molecules. In order to explore the active metabolites of the fungi Marasmius berteroi, the deep chemical investigation on the bioactive compounds from its cultures was undertaken, which led to the isolation of three new naphthalene compounds dipolynaphthalenes A–B (1,2) and naphthone C (3), as well as 12 known compounds (4–15). Compounds 1, 2, and 4 are dimeric naphthalene compounds. Their structures were elucidated by MS, 1D and 2D NMR spectroscopic data, as well as ECD calculations. Compounds 2–4 and 7 exhibited acetylcholinesterase (AChE) inhibitory activities at the concentration of 50 μg/mL with inhibition ratios of 42.74%, 44.63%, 39.50% and 51.49%, respectively. Compounds 5 and 7,8 showed weak inhibitory activities towards two tumor cell lines, with IC50 of 0.10, 0.076 and 0.058 mM (K562) and 0.13, 0.18, and 0.15 mM (SGC-7901), respectively.
Highlights
Natural products are an important source of innovative chemical drugs [1]
The IR (Supplementary Materials) spectrum revealed the presence of hydroxyl (3305 cm−1 ) and benzene ring (1581cm−1 ) absorptions
According to a comparison of the corresponding NMR data, compound 1 was similar to nodulisporin
Summary
Natural products are an important source of innovative chemical drugs [1]. Finding natural active ingredients for nerve protection and tumor suppression are hot topics in the current research [2].The genus Marasmius is a common basidiomycete in tropical and subtropical areas, which belongs to the family Marasmiaceae [3]. A few common species of Marasmius have been studied for searching of bioactive metabolites, and some active compounds such as terpenoids [4,5,6,7,8], steroids [9], cyclic peptides [10], isocoumarins [11] and piperidones [12] have been isolated. Many of these compounds showed antibacterial, cytotoxic and antihypertensive activities [9,10,11,12].
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