Abstract
The reaction of alkyl aryl sulfones 1 with an excess of lithium powder and a catalytic amount of naphthalene (8 mol %) in the presence of a carbonyl compound [Pr iCHO, PhCHO, Et 2CO, ( CH 2) 5CO] or trimethylchlorosilane (Barbier-type conditions) in THF at temperatures ranging between −78 and 20°C leads, after hydrolysis with water, to the expected coupling products, arising from the corresponding alkyllithium in situ generated, in 30–61% yields.
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